Research Journal of Pharmacology and Pharmacodynamics

K. Prasad ¹, M. Nitin ², M. Chetan ³, M. Girish ³, Krishna Kumar ³

Affiliations
1 Shri Vishnu College of Pharmacy, Bhimavaram-534202, A.P., IN
2 HKES College of Pharmacy, Department of Pharmacology, Sedam Road, Gulbarga-585105, Karnataka, IN
3 HKES College of Pharmacy, Department of Pharmacology, Gulbarga-585105, Karnataka, IN

Abstract

Peptic ulcer is a chronic and appalling disease. Today, it is dominant among the diseases that affect the world's population. The principal factors causing this disease are inadequate dietetic habits, prolonged use of non-steroidal anti-inflammatory drugs, stress and infection by Helicobacter pylori, in addition to other factors of genetic origin. The present study was designed to evaluate the combination effect of vitamin E with lansoprazole against pylorus ligation induced ulcer model in rats. The antiulcer effect of the combination of vitamin E 0.9mg/200g and lansoprazole 0.54mg/200g b.w. orally was compared with the reference standard lansoprazole 0.54mg/200 g b.w. orally. The ulcer index and other biochemical parameters like volume, pH, free acidity and total acidity of gastric juice were estimated. The ulcer index and other biochemical parameters like volume (***P < 0.001), free acidity (***P < 0.001), total acidity (***P < 0.001) and pH (**P < 0.01), of gastric juice showed reduction when compared to standard lansoprazole. The percentage protection of combination was 92.9% as compared to standard lansoprazole 82.8%. Thus the combination group was found to be synergistic in nature when compared to lansoprazole alone.

Keywords

Antiulcer Activity, Vitamin E, Lansoprazole, Pylorus Ligation Model, Ulcer Index.

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